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compound 11b  (Selleck Chemicals)


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    Selleck Chemicals compound 11b
    Compound 11b, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 96/100, based on 1284 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/compound+11b/Compound/pm38060985__jm3c01362_si_001-17-8-125
    Average 96 stars, based on 1284 article reviews
    compound 11b - by Bioz Stars, 2026-10
    96/100 stars

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    Article Title: Discovery of Dual Function Agents That Exhibit Anticancer Activity via Catastrophic Nicotinamide Adenine Dinucleotide Depletion.
    Article Snippet: .. NAD depletion accounts for the antitumor effect of compound 11b. (A) Cell viability of LN18 cells was examined by cell violet staining assay after treatment with compound 11b and the indicated concentrations of PARPi (Rucaparib). (B) Cell viability of LN-18 cells was examined after compound 11b treatment with/without simultaneous supplement of NAM for 72 hours. (C) Cell viability of LN-18 cells was examined after compound 11b treatment with/without simultaneous supplement of NMN for 72 hours. (D) Cell viability of B16 cells was examined after compound 11b treatment with/without simultaneous supplement of NAD for 72 hours. (E) Cell viability of LN18 cells was examined by cell violet staining assay after treatment with compound 11b and Sellisistat (1 μM), 3-TRP (1 μM) or NNMTi (Compound 1k from Selleck, 1 μM) for 72 hours. ..



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    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / <t>11f</t> : R 1 = C 5 H 11 , R 2 = H).
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    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / <t>11f</t> : R 1 = C 5 H 11 , R 2 = H).
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    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / <t>11f</t> : R 1 = C 5 H 11 , R 2 = H).
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    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / <t>11f</t> : R 1 = C 5 H 11 , R 2 = H).
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    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / <t>11f</t> : R 1 = C 5 H 11 , R 2 = H).
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    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / <t>11f</t> : R 1 = C 5 H 11 , R 2 = H).
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    Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / 11f : R 1 = C 5 H 11 , R 2 = H).

    Journal: International Journal of Molecular Sciences

    Article Title: Naphthoquinone-Quinolone Hybrids with Antitumor Effects on Breast Cancer Cell Lines—From the Synthesis to 3D-Cell Culture Effects

    doi: 10.3390/ijms25126490

    Figure Lengend Snippet: Synthetic route towards 1,4-naphthoquinone/4-quinolone conjugates. a: (1) EMME, EtOH; (2) Diphenylether, 250 °C; b: (1) K 2 CO 3 , DMF, r. t., 15 min. (2) R1-X, DMF, 80 °C, 24 h.; c: H 2 (20 bar), Pd/C (10%), EtOH, 50 °C, 3 h. (for R1 = ethyl and pentyl); d: NH 4 Cl 0,05 M, Fe, reflux (for R1 = benzyl); e: (1) NaOH, EtOH, r. t. (2) H 2 O, HCl; f: t-butyl nitrite, DMSO, H 2 O, 1,4-naphthoquinone, ultrasound, 25 °C. ( 15a/11a : R 1 = Et, R 2 = Et; 15b/11b : R 1 = Bn, R 2 = Et; 15c / 11c : R 1 = Pentyl, R 2 = Et; 16a / 11d : R 1 = Et, R 2 = H; 16b / 11e : R 1 = CH 2 C 6 H 5 , R 2 = H; 16c / 11f : R 1 = C 5 H 11 , R 2 = H).

    Article Snippet: Additionally, compounds 11a , 11b , 11d , 11e , and 11f exhibited zero violations of the drug-likeness rules of Lipinski, Ghose, Veber, Egan, and Muegge.

    Techniques: Reflux

    IC 50 values and selectivity indices (SI) of 1,4-naphthoquinone, compounds 11a–f , and doxorubicin.

    Journal: International Journal of Molecular Sciences

    Article Title: Naphthoquinone-Quinolone Hybrids with Antitumor Effects on Breast Cancer Cell Lines—From the Synthesis to 3D-Cell Culture Effects

    doi: 10.3390/ijms25126490

    Figure Lengend Snippet: IC 50 values and selectivity indices (SI) of 1,4-naphthoquinone, compounds 11a–f , and doxorubicin.

    Article Snippet: Additionally, compounds 11a , 11b , 11d , 11e , and 11f exhibited zero violations of the drug-likeness rules of Lipinski, Ghose, Veber, Egan, and Muegge.

    Techniques:

    Physicochemical parameter values for compounds 11a–f using Swiss ADME server.

    Journal: International Journal of Molecular Sciences

    Article Title: Naphthoquinone-Quinolone Hybrids with Antitumor Effects on Breast Cancer Cell Lines—From the Synthesis to 3D-Cell Culture Effects

    doi: 10.3390/ijms25126490

    Figure Lengend Snippet: Physicochemical parameter values for compounds 11a–f using Swiss ADME server.

    Article Snippet: Additionally, compounds 11a , 11b , 11d , 11e , and 11f exhibited zero violations of the drug-likeness rules of Lipinski, Ghose, Veber, Egan, and Muegge.

    Techniques: